Increased expression of GAD65 and GABA in pancreatic b-cells impairs first-phase insulin secretion
نویسندگان
چکیده
YUGUANG SHI, JAMIL KANAANI, VIRGINIE MENARD-ROSE, YAN HUI MA, PI-YUN CHANG, DOUGLAS HANAHAN, ALLAN TOBIN, GEROLD GRODSKY, AND STEINUNN BAEKKESKOV Departments of Medicine, Microbiology and Immunology, and Hormone Research Institute, Department of Biochemistry and Biophysics and Metabolic Research Unit, Department of Biochemistry and Biophysics and Hormone Research Institute, School of Medicine, University of California, San Francisco 94143; and Department of Biology, University of California, Los Angeles, California 90095
منابع مشابه
Increased expression of GAD65 and GABA in pancreatic beta-cells impairs first-phase insulin secretion.
The functional role of glutamate decarboxylase (GAD) and its product GABA in pancreatic islets has remained elusive. Mouse beta-cells express the larger isoform GAD67, whereas human islets express only the smaller isoform GAD65. We have generated two lines of transgenic mice expressing human GAD65 in pancreatic beta-cells (RIP7-hGAD65, Lines 1 and 2) to study the effect that GABA generated by t...
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